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Classic usage
Reading level: hard
Estimated CEFR level: C2 — Proficiency
Estimated from word frequency; not an official CEFR classification.
From the plural of Middle English pocke. See also pock. The curse sense involves metonymy: wishing a literal pox upon someone is the original form of pox-relevant curse, and the word pox itself also came to mean curse.
syphilis, syph, lues venerea, lues
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Classic usage
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