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Classic usage
Estimated CEFR level: C2 — Proficiency
Estimated from word frequency; not an official CEFR classification.
From New Latin syphilis, originally the title of a poem, circa 1530, by Girolamo Fracastoro concerning “Syphilus”, a shepherd boy who insulted the Greek god Apollo and was punished by that god with a horrible disease. Syphilis in the Old World began circa 1495; its spread is believed to be part of the Columbian Exchange. More in Wikipedia at History of syphilis.
syph, pox, lues venerea, lues
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Classic usage
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